Abstract
A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.
MeSH terms
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Drug Evaluation
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HIV Reverse Transcriptase / drug effects*
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Quinoxalines / chemical synthesis*
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Quinoxalines / pharmacology*
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / pharmacology*
Substances
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Quinoxalines
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase